|
CK20- |
- Breast (BCDP, ER/PR, Her-2/Neu)
- Lung (TTF-1)
- Serous ovarian (psammoma bodies, WT-1)
- Endometrial (ER/PR)
- Mesothelioma (calretinin)
- Thymoma (psammoma bodies, T-cell
markers)
|
- Liver (hepatocyte antigen)
- Renal
- Prostate (PSA)
- Squamous (CK5+ or CK6+)
- Neuroendocrine (chromogranin A, synaptophysin,
neuron-specific enolase)
- Melanoma (S100, HMB45, tyrosinase-related
protein, vimentin)
- Lymphoma (CD45 [LCA] positive, B-cell or T-cell
marker positive, pancytokeratin negative)
|
|
BCDP, breast cystic disease protein; CK, cytokeratin;
ER, estrogen receptor; PR, progesterone receptor; PSA,
prostate-specific
antigen; TTF-1, thyroid transcription factor-1; WT-1, Wilms' tumor
protein-1.
*Gastric cancer may have any of the four patterns of expression of
CK7 and CK20. Wang NP, Zee S, Zarbo RJ, Bacchi CE,
Gown AM. Coordinate expression of cytokeratins 7 and 20 defines
unique subsets
of carcinomas. Appl Immunohistochem 3:99, 1995.
Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression
in epithelial neoplasms: a survey of 435 cases.
Mod Pathol 13:962, 2000. |
